ETH Zurich and University of Zurich researchers have combined neural progenitor cells with magnetoelectric nanoparticles to create microrobots that can be guided and stimulated using external magnetic fields. The particles turn magnetic signals into electrical stimulation, encouraging the transplanted cells to develop into nerve cells without implanted electrodes. A microfluidic production system assembles the cell-particle combinations.
In injured zebrafish larvae, the treatment restored nearly normal swimming and exploratory behaviour within three days. Mice with completely severed spinal cords showed substantial improvements in movement over four weeks, alongside neural repair at the injury site. These are preclinical results: long-term particle clearance, suitable stimulation settings and safety must be established before human testing.
